Neo X is now connected to LayerZero’s permissionless omni-chain infrastructure, enabling cross-chain interactions, liquidity flow, and composable applications across more than 170 blockchain networks. Neo Global Development announced the partnership on April 14, marking the completion of MainNet integration for the EVM-compatible sidechain.
The milestone fulfills an integration agreement signed in March, when Neo co-founder Da Hongfei first announced that LayerZero would deploy on Neo X with a TestNet target by the end of that month. In an interview with Tanzeel Akhtar on April 10, Da confirmed that TestNet deployment had been completed on schedule and that MainNet implementation would follow shortly.
How the integration works
LayerZero is an omni-chain messaging protocol. Rather than using a traditional bridge model that locks and mints wrapped assets, it enables direct chain-to-chain communication through on-chain endpoints. When a smart contract sends a cross-chain message, the endpoint assigns verification to configurable Decentralized Verifier Networks and delegates execution to an Executor, which triggers message delivery on the destination chain. The protocol’s Omnichain Fungible Token standard allows tokens to be transferred natively across supported chains without asset wrapping or middlechains.
LayerZero deployed its contracts on Neo X TestNet and cross-chain testing was completed for both token and NFT assets ahead of the MainNet deployment, as reported last week. Integration of the USD1 stablecoin via LayerZero was also in progress as of April 9, though no completion timeline has been provided.
Cross-chain strategy
The LayerZero integration expands Neo X’s external connectivity beyond its existing Message Bridge to Neo N3, which launched in December 2025. Where the Message Bridge handles interoperability within Neo’s own ecosystem, LayerZero opens access to external networks, including EVM chains, Solana, and Sui.
Da noted in March that Neo N3 integration with LayerZero is under separate negotiation. The two chains face different fee structures, and Neo N3 was quoted at 14 times the integration cost of Neo X.
AI agent positioning
NGD framed the partnership in part as infrastructure for Neo X’s AI agent strategy, stating that “AI agents can now move, act, and coordinate across networks.” Da has been positioning Neo X as an AI-agent-native blockchain since March, and cross-chain connectivity is a component of that vision, enabling agents to interact with assets and protocols across multiple networks. However, the LayerZero integration is a general-purpose infrastructure layer, not an AI-specific product.
The partnership gives Neo X access to one of the most widely deployed cross-chain messaging protocols in the industry, with LayerZero claiming to have facilitated over US $200 billion in historical volume across its supported networks.
The original announcement can be found at the link below:
https://x.com/ngd_neo/status/2043905657213202598